Ca2+ Shuttling during Ca2+ Oscillations in Mesothelial Cells [Computational Biology]

In some cell types, Ca2+ oscillations are strictly dependent on Ca2+ influx across the plasma membrane, whereas in others, oscillations also persist in the absence of Ca2+ influx. We observed that, in primary mesothelial cells, the plasmalemmal Ca2+ influx played a pivotal role. However, when the Ca2+ transport across the plasma membrane by the “lanthanum insulation method” was blocked prior to the induction of the serum-induced Ca2+ oscillations, mitochondrial Ca2+ transport was found to be able to substitute for the plasmalemmal Ca2+ exchange function, thus rendering the oscillations independent of extracellular Ca2+. However, in a physiological situation, the Ca2+-buffering capacity of mitochondria was found not to be essential for Ca2+ oscillations. Moreover, brief spontaneous Ca2+...

from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=152143618&cid=c_409_59_f&fid=32070&url=http%3A%2F%2Fwww.jbc.org%2Fcontent%2F290%2F47%2F28214.short%3Frss%3D1