In this study we sought to determine the role of cigarette smoke in MPE using a mesothelioma-induced MPE syngeneic model. C57BL/6 mice were exposed upon 4 weeks CS (3R4F University of Kentucky, USA). At the 2nd week of smoking the mice were subjected to intrapleural injection of AE17 cells. Control animals were exposed to room air. CS-exposed group presented significantly (p=0.002) larger pleural effusions (1018±87.7μl) compared to control (697±88.8μl). Tumor size was similar between groups. Interestingly, CS-exposed mice exhibited higher numbers of tumor promoting, M2-polarized macrophages. We also investigated the effect of cigarette smoke in naive, tumor intact, animals. We witnessed increased pleural cellularity, pleural neutrophil and pro-tumor T-regulatory cell ac...
from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=146296715&cid=c_409_40_f&fid=40789&url=http%3A%2F%2Ferj.ersjournals.com%2Fcgi%2Fcontent%2Fshort%2F46%2Fsuppl_59%2FPA4343%3Frss%3D1
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