Overexpression or absence of calretinin in mouse primary mesothelial cells inversely affects proliferation and cell migration

Conclusions: We hypothesize that the differences in proliferation and mobility between WT and CR−/− mesothelial cells are the likely result from differences in their developmental trajectories. The mechanistic understanding of the function of calretinin and its putative implication in signaling pathways in normal mesothelial cells may help understanding its role during the processes that lead to mesothelioma formation and could possibly open new avenues for mesothelioma therapy, either by directly targeting calretinin expression or indirectly by targeting calretinin-mediated downstream signaling. (Source: Respiratory Research)

from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=160021080&cid=c_409_40_f&fid=34092&url=http%3A%2F%2Frespiratory-research.com%2Fcontent%2F16%2F1%2F153