The diagnosis of malignant mesothelioma in effusion cytology specimens is controversial. BAP1 immunohistochemistry and p16 fluorescence in situ hybridization (FISH) have recently been reported as reliable markers of malignancy in biopsies of mesothelioma. To determine whether these markers, singly or in combination, might also be useful in effusion cytology specimens, we examined 15 biopsies of epithelial mesotheliomas and 3 benign mesothelial reactions and corresponding effusion cytology paraffin-embedded cell blocks. Four cytology specimens were too scanty for p16 FISH analysis but were interpretable for BAP1 immunohistochemistry. Overall, loss of BAP1 and/or deletion of p16 was seen in 11/11 (100%) of matched cytology and tissue biopsy specimens. BAP1 loss alone was seen in 10/15 (67%) ...
from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=157411785&cid=c_409_32_f&fid=34248&url=http%3A%2F%2Fjournals.lww.com%2Fajsp%2FFulltext%2F2016%2F01000%2FUtility_of_BAP1_Immunohistochemistry_and_p16.15.aspx
Enregistrer un commentaire