Abstract Malignant mesothelioma (MM) is a fatal cancer of the pleural and peritoneal cavities caused predominantly by exposure to asbestos. Cohort studies suggest a genetic component to MM susceptibility. BAP1 is a tumour suppressor gene located at 3p21 and is one of the most commonly somatically lost or mutated genes in MM, occurring in approximately 40–60 % of tumours. Germline mutations in BAP1 appear to increase susceptibility to asbestos-induced MM. However, the frequency of germline BAP1 mutation is rare, not being observed in over 300 sporadic MM cases. Germline BAP1 mutation is characteristic of a heritable cancer predisposing syndrome with affected individuals developing malignancies such as MM, uveal and cutaneous melanoma at relatively high frequency. Here, we review...
from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=162039109&cid=c_409_40_f&fid=39442&url=http%3A%2F%2Flink.springer.com%2F10.1007%2Fs13665-016-0132-1
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