Germline BAP1 Mutations in Mesothelioma Patients

Heritable mutations in the BAP1 tumor suppressor gene predispose individuals to mesothelioma and other cancers. However, a large-scale assessment of germline BAP1 mutation incidence and associated clinical features in mesothelioma patients with a family history of cancer has not been reported. Therefore, we examined the germline BAP1 mutation status of 150 mesothelioma patients with a family history of cancer, 50 asbestos-exposed control individuals with a family history of cancers other than mesothelioma, and 153 asbestos-exposed individuals without familial cancer. No BAP1 alterations were found in control cohorts, but were identified in nine of 150 mesothelioma cases (6%) with a family history of cancer. Alterations among these cases were characterized by both missense and frameshift mu...

from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=162127992&cid=c_409_6_f&fid=33679&url=http%3A%2F%2Fcancerres.aacrjournals.org%2Fcontent%2F76%2F2%2F206.short%3Frss%3D1