Mesothelin: A Rising Star in Cancer Immunotherapy [Review]

Chimeric antigen receptors (CAR) are synthetic receptors that target T cells to cell-surface antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen implicated in tumor invasion, which is highly expressed in mesothelioma and lung, pancreas, breast, ovarian, and other cancers. Its low-level expression in mesothelia, however, commands thoughtful therapeutic interventions. Encouragingly, recent clinical trials evaluating active immunization or immunoconjugates in patients with pancreatic adenocarcinoma or mesothelioma have shown responses without toxicity. Altogether, these findings and preclinical CAR therapy models using either systemic or regional T-cell delivery argue favorably for mesothelin CAR therapy in multiple solid tumors. Significance: Recent suc...

from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=164733119&cid=c_409_6_f&fid=40732&url=http%3A%2F%2Fcancerdiscovery.aacrjournals.org%2Fcgi%2Fcontent%2Fshort%2F6%2F2%2F133%3Frss%3D1