Authors: Kari T, Ylermi S, Paavo P, Jyrki P, Reijo S, Kirsi R Abstract Hyaluronan is a unique glycosaminoglycan of the extracellular matrix, abundant in normal connective tissues but highly increased in many pathological conditions like cancer. Mesothelioma, one of the most malignant cancer types, is associated with high content of hyaluronan, with elevated levels of hyaluronan in pleural effusions and serum of the patients. Metastatic lung adenocarcinomas are typically less aggressive and have a better prognosis as compared to mesotheliomas, a reason why it is highly important to find reliable tools to differentiate these cancer types. The main purpose of this study was to evaluate the amount of hyaluronan, hyaluronan producing synthases (HAS's) and hyaluronan receptor CD44, in me...
from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=167695376&cid=c_409_171_f&fid=41015&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26912058%3Fdopt%3DAbstract
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