Authors: Sun M, Tang H, Gao Y, Dai X, Yuan Y, Zhang C, Sun D Abstract Onconase is an RNase of the ribonuclease A superfamily that is purified from the Northern leopard frog (Rana pipiens). It targets several types of malignant tumors, digests cytoplasmic transfer RNA (tRNA), and causes tumor cell apoptosis. Onconase has been employed in clinical trials as an antitumor drug, and has revealed its valuable clinical activity in several types of tumors, particularly pleural mesothelioma. However, its inefficiency in targeting tumor cells and its non‑specific toxicity in normal tissues have diminished its clinical benefits. Furthermore, cyclization of the N-terminal glutamine residue (Gln), possesses more RNase activity than the structure of Met ahead of Glu in the N-terminal (99:1), ...
from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=162909160&cid=c_409_6_f&fid=40952&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26782924%3Fdopt%3DAbstract
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