Multipolar mitosis and aneuploidy after chrysotile treatment: a consequence of abscission failure and cytokinesis regression.

Authors: Cortez BA, Teixeira PR, Redick S, Doxsey S, Machado-Santelli GM Abstract Chrysotile, like other types of asbestos, has been associated with mesothelioma, lung cancer and asbestosis. However, the cellular abnormalities induced by these fibers involved in cancer development have not been elucidated yet. Previous works show that chrysotile fibers induce features of cancer cells, such as aneuploidy, multinucleation and multipolar mitosis. In the present study, normal and cancer derived human cell lines were treated with chrysotile and the cellular and molecular mechanisms related to generation of aneuploid cells was elucidated. The first alteration observed was cytokinesis regression, the main cause of multinucleated cells formation and centrosome amplification. The multinucle...

from MedWorm: Mesothelioma http://www.medworm.com/index.php?rid=162909144&cid=c_409_6_f&fid=40741&url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F26788989%3Fdopt%3DAbstract